-教師資料-

姓名：傅淑玲

職稱：教授

連絡電話：(02)2826-7177

電子信箱：slfu@nycu.edu.tw

 現職：國立陽明交通大學傳統醫藥研究所教授

學經歷：

美國紐約州立大學石溪分校生化及細胞生物學博士

美國Scripps研究中心分子實驗醫學部博士後研究員

學術獎項：

陽明大學教師學術卓越獎勵 (2017~2022)

院級教學傑出獎 (2021)

研究專長：

癌症生物學、分子生物學、抗癌天然物及中草藥、抗發炎天然物及中草藥

研究方向：

1. 抗癌天然物藥理活性分析及作用機轉探討
2. 降低癌化療副作用之天然藥物與醫藥組合物
3. 抗發炎天然物的篩選及藥理活性分析
4. 抑制新冠病毒的天然藥物開發

開設課程：

抗癌天然物作用機轉、中醫藥實驗概論、傳統醫藥學概論

期刊審查委員: 

Biochemical Pharmacology

Journal of Agricultural and Food Chemistry

Frontiers in Pharmacology

Phytomedicine

Phytochemistry

International Immunopharmacology

Pharmacological Research

Cell Death and Disease　

British Journal of Pharmacology

Evidence-Based Complementary and Alternative Medicine

Experimental and Molecular Medicine

Molecules

Journal of Biomedical Science　

Evidence-Based Complementary and Alternative Medicine

BMC cancer

Journal of Functional Food

1. 論文 (2011~ 迄今)

   1. Yi-Ju Chou, Ching-Cheng Lin, Ya-chi Hsu, Jia-Ling Syu, Ling-Ming Tseng, Jen-Hwey Chiu, Jeng-Fan Lo, Chao-Hsiung Lin, and Shu-Ling Fu* (2022),“Andrographolide suppresses the malignancy of triple-negative breast cancer by reducing THOC1-promoted cancer stem cell characteristics”, Biochemical Pharmacology (in press).
   2. Kai-Wei Chang, Tung-Yi Lin, Shu-Ling Fu, Yueh-Hsin Ping, Fang-Pey Chen, Yen-Ying Kung (2022), “A Houttuynia cordata-based Chinese herbal formula improved symptoms of allergic rhinitis during the COVID-19 pandemic”, Journal of the Chinese Medical Association, 85:717-722.
   3. Yueh-Hsin Ping, Hsin Yeh, Li-Wei Chu, Zhi-Hu Lin, Yin-Chieh Hsu, Lie-Chwen Lin, Chung-Hua Hsu, Shu-Ling Fu*, Tung-Yi Lin* (2022), “The Traditional Chinese Medicine Formula Jing Guan Fang for preventing SARS-CoV-2 infection: from clinical observation to basic research”, Frontiers in Pharmacology, 13:744439.
   4. Yi-Cheng Chu, Chang-Syun Yang, Ming-Jen Cheng, Shu-Ling Fu*, and Jih-Jung Chen* (2022), “Comparison of various solvent extracts and major bioactive components from unsalt-fried and salt-fried rhizomes of Anemarrhena asphodeloides for antioxidant, anti-α-Glucosidase, and anti-acetylcholinesterase activities”, Antioxidants, 11: 385.
   5. Yi-Hue Kuo, Shih-Hsiang Wei, Jie-Hau Jiang, Yueh-Shih Chang, Mei-Yin Liu, Shu-Ling Fu, Chi-Ying F Huang, Wey-Jinq Lin* (2021), “Perturbation of p38α MAPK as a Novel Strategy to Effectively Sensitize Chronic Myeloid Leukemia Cells to Therapeutic BCR-ABL Inhibitors”, International Journal of Molecular Sciences, 22:12573.
   6. Lin-Chieh Chiu, Jir-You Wang, Chao-Hsiung Lin, Chung-Hua Hsu, Lie-Chwen Lin* and Shu-Ling Fu* (2021), “Diterpenoid compounds isolated from Chloranthus oldhamii Solms exert anti-inflammatory effects via inhibiting IKK/NF-κB pathways”, Molecules, 26: 6540.
   7. Chien-Tung Wu, Yueh-Ting Tsai, Hsuan-Kuang Jung, Shu-ling Fu, Chao A. Hsiung, Hsiao-Yu Liu, Jung-Nien Lai (2021), “Metformin and the risk of anemia of advanced chronic kidney disease in patients with Type 2 Diabetes mellitus”, The Journal of Clinical Pharmacology, 62:276-284.
   8. Chiao-Che Chen, Jen-Hao Yang, Shu-Ling Fu, Wey-Jinq Lin and Chao-Hsiung Lin* (2021), “Arginine methylation of hnRNPK inhibits the DDX3-hnRNPK interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells”, International Journal of Molecular Sciences, 22: 9764.
   9. Yi-Cheng Chu, Chun-Hao Chang, Hsiang-Ruei Liao, Shu-Ling Fu and Jih-Jung Chen* (2021), “Anti-cancer and anti-Inflammatory activities of three new chromone derivatives from the marine-derived Penicillium citrinum”, Marine Drugs, 19: 408.
   10. Yi-Cheng Chu, Chun-Hao Chang, Hsiang-Ruei Liao, Ming-Jen Cheng, Ming-Der Wu, Shu-Ling Fu* and Jih-Jung Chen* (2021), “Rare chromone derivatives from the marine-Derived Penicillium citrinum with anti-cancer and anti-Inflammatory activities”, Marine Drugs, 19: 25.
   11. Cai-Wei Li, Yi-Cheng Chu, Chun-Yi Huang, Shu-Ling Fu and Jih-Jung Chen (2020) “Evaluation of Antioxidant and Anti-α-glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Seeds of Myristica fragrans”, Molecules, 25:5198.
   12. Tzu-Hau Shi, Yi-Long Huang, Chiao-Che Chen, Wen-Chieh Pi, Yu-Ling Hsu, Lee-Chiang Loe Wei-Yi Chen, Shu-Ling Fu*, Chao-Hsiung Lin* (2020) “Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage”, Biochemical and Biophysical Research Communications, 533(3):467-473 (corresponding author).
   13. Yi-Ju Chou, Ching-Cheng Lin, Ivan Dzhagalov, Nien-Jung Chen, Chao-Hsiung Lin, Chun-Cheng Lin, Szu-Ting Chen, Kuo-Hsin Chen* and Shu-Ling Fu* (2020) “Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy”, Scientific Reports, 10: 8422 (corresponding author).
   14. Hsin-Yu Tsai, Shu-Ling Fu, Ling-Ming Tseng, Jen-Hwey Chiu & Chao-Hsiung Lin (2019) “hnRNPK S379 phosphorylation participates in migration regulation of triple negative MDA-MB-231 cells” Scientific Reports, 9: 7611.
   15. Hsin-Chia Liao, Yi-Ju Chou, Ching-Cheng Lin, Sheng-Hung Liu, Audrey Oswita, Yi-Long Huang, Ying-Lien Wang, Jia-Ling Syu, Chung-Ming Sun, Chuen-Miin Leu, Chao-Hsiung Lin and Shu-Ling Fu* (2019) “Andrographolide and its potent derivative exhibit anticancer effects against imatinib-resistant chronic myeloid leukemia cells by downregulating the Bcr-Abl oncoprotein”. Biochemical Pharmacology, 163: 308-320 (corresponding author).
   16. Yun-Chen Tsai, Sin-Ling Wang, Mei-Yao Wu, Chia-Huei Liao, Chao-Hsiung Lin, Jih-Jung Chen* and Shu-Ling Fu* (2018)“Pilloin, a flavonoid isolated from Aquilaria sinensis, exhibits anti-inflammatory activity in vitro and in vivo” Molecules, 23: e3177 (corresponding author).
   17. Chih-Chia Yu, Chien-An Chen, Shu-Ling Fu, Hon-Yi Lin, Moon-Sing Lee, Wen-Yen Chiou, Yu-Chieh Su, Shih-Kai Hung (2018) “Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity” PLOS one, 13: e0205666.
   18. Lin-Yang Cheng, Yun-Chen Tsai, Shu-Ling Fu, Ming-Jen Cheng, Ping-Jyun Sung, Mei-Ing Chung and Jih-Jung Chen (2018) “Acylphloroglucinol Derivatives from Garcinia multiflora with Anti-Inflammatory Effect in LPS-Induced RAW264.7 Macrophages ” Molecules, 23: e2587.
   19. Sin-Ling Wang , Yun-Chen Tsai , Shu-Ling Fu, Ming-Jen Cheng, Mei-Ing Chung and Jih-Jung Chen (2018) “2-(2-Phenylethyl)-4H-chromen-4-one Derivatives from the Resinous Wood of Aquilaria sinensis with Anti-Inflammatory Effects in LPS-Induced Macrophages” Molecules, 23: e289.
   20. Chien-Tung Wu, MD, Yueh-Ting Tsai, Jaung-Geng Lin, Shu-ling Fu, Jung-Nien Lai* (2018) “Chinese herbal products and the reduction of risk of breast cancer among females with type 2 diabetes in Taiwan “ Medicine, 97:e11600.
   21. Yun-Chen Tsai, Shih-Han Chen, Lie-Chwen Lin*, and Shu-Ling Fu*(2017) “Anti-inflammatory principles from Sarcandra glabra” Journal of Agricultural and Food Chemistry, 65: 6497-6505 (corresponding author).
   22. Shu-ling Fu, Chien-an Chen, Ling-chien Hung, Moon-Sing Lee, Wen-yen Chiou, Hon-Yi-Lin, Yu-Chien Su, Ching-Chih Lee and Shih-Kai Hung (2016) “Preliminary results of a non-invasive method to measure tumor size and distribution in vivo” Experimental and Therapeutic Medicine, 12: 3614-3620.
   23. Ya-Hsin Hsu, Yu-Ling Hsu, Sheng-Hung Liu, Hsin-Chia Liao, Po-Xuan Lee, Chao-Hsiung Lin, Lee-Chiang Lo, and Shu-Ling Fu* (2016) “Development of a bifunctional andrographolide-based chemical probe for pharmacological study” PLOS one, 11: e0152770 (corresponding author).
   24. Shu-Ling Fu, Chun-Cheng Lin, Ming-Ling Hsu, Yu-Jen Chen* (2016) ” CCL-34, a synthetic Toll-like receptor 4 activator, modulates differentiation and maturation of myeloid dendritic cells” Oncotarget, 7:11677
   25. Yu-Ling Hsu, Chun-Chieh Yang, Tzyy-Chao Chou, Chih-Hsuan Tai, Long-Yuan Chen, Shu-Ling Fu, Jing-Jer Lin, Lee-Chiang Lo* (2016) “Design, synthesis, and evaluation of cell permeable probes for protein kinases” Tetrahedron, 72: 58-68.
   26. Ya-Wei Liu, Yung-Tsung Chiu, Shu-Ling Fu, Yi-Tsau Huang* (2015) ” Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation” Journal of Biomedical Science, 22:63.
   27. Tsai-Feng Li, Ching-Cheng Lin, Hui-ping Tsai, Chung-Hua Hsu*, Shu-Ling Fu* (2014) “Effects of Kuan-Sin-Yin decoction on immunomodulation and tumorigenesis in mouse tumor models” BMC Complementary and Alternative Medicine, 14:488 (corresponding author).
   28. Yu-Chieh Su, Chih-Chia Yu, Fei-Ting Hsu, Shu-Ling Fu, Jeng-Jong Hwang, Ling-Chien Hung, Moon-Sing Lee, Wen-Yen Chiou, Hon-Yi Lin, Shih-Kai Hung (2014) “Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway” International Journal of Molecular Medicine, 34: 1417-1422.
   29. Sheng-Hung Liu, Chao-Hsiung Lin, Fong-Ping Liang, Pei-Fen Chen, Cheng-Deng Kuo, Mujahid Alam, Barnali Maiti, Shih-Kai Hung, Chin-Wen Chi, Chung-Ming* Sun and Shu-Ling Fu* (2014) “Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy” Biochemical Pharmacology, 87:229-242 (corresponding author)..
   30. Jen-Hao Yang, Yi-Ying Chiou, Shu-ling Fu, I-Yun Shih, Tsai-Hsuan Weng, Wey-Jinq Lin and Chao-Hsiung Lin (2014) “Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation” Nucleic Acids Research, 42:9908-24.
   31. Yu-Ling Chang, Tzu-Hui Chen, Yi-Hsiu Wu, Guann-An Chen, Tzu-Huei Weng, Ping-Hui Tseng, Shie-Liang Hsieh, Shu-Ling Fu, Chi-Hung Lin, Chun-Jen Chen, Ching-Liang Chu, Iok In Christine Chio, Tak Wah Mak*and Nien-Jung Chen* (2014) “A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction” Journal of Cellular and Molecular Medicine 18:1344-57.
   32. Yong-Shiang Lin, Chao-Hsiung Lin, Li-De Huang, Tung Chao, Cheng-Deng Kuo, Ling-Chien Hung, Fen-Hwa Wong, Chun-Cheng Lin* and Shu-Ling Fu* (2013) “Suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent” Biochemical Pharmacology, 86: 242-252 (corresponding author).
   33. Kai-Wei Hsueh, Shu-Ling Fu, Chirn-Bin Chang, Yu-Ling Chang and Chao-Hsiung Lin (2013) “A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2” BBA - Proteins and Proteomics, 1834:508-515.
   34. Yi-Ying Chiou, Shu-Ling Fu, Wey-Jinq Lin, and Chao-Hsiung Lin (2012) “Proteomics analysis of in vitro protein methylation during Src-induced transformation” Electrophoresis, 33: 451-461.
   35. Yong-Shiang Lin, Li-De Huang, Chao-Hsiung Lin, Po-Hsiung Huang, Yu-Jen Chen, Fen-Hwa Wong, Chun-Cheng Lin*, and Shu-Ling Fu* (2011) “In vitro and in vivo anticancer activity of a synthetic glycolipid as TLR4 activator” Journal of Biological Chemistry, 286: 43782-43792 (corresponding author).
   36. Mei-Yao Wu, Shih-Kai Hung and Shu-Ling Fu* (2011) “Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-κB activity” Journal of Agricultural and Food Chemistry, 59: 10496-10504 (corresponding author).
   37. Kai-Wei Hsueh, Shu-Ling Fu, Chi-Ying F. Huang and Chao-Hsiung Lin (2011) ^“Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53” FEBS letters, 585: 2671-2675.
   38. Chia-Yuan Liu, Hsun-Shuo Chang, Ih-Sheng Chen, Chih-Jen Chen, Ming-Ling Hsu, Shu-Ling Fu^*, Yu-Jen Chen^* (2011) “Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells” Radiation Oncology, 6: 56 (corresponding author). `
   39. Li-De Huang, Hong-Jyune Lin, Po-Hsiung Huang, Wei-Chen Hsiao, L. Vijaya Raghava Reddy, Shu-Ling Fu* and Chun-Cheng Lin* (2011) “Synthesis of serine-based glycolipids as potential TLR4 activators” Organic & Biomolecular Chemistry, 9: 2492-2504 (corresponding author).

-研究計畫-(請提供5年內計畫)

科技部計畫：

1. 探討穿心蓮內酯及其衍生物應用於胰臟癌之新穎分子機轉及治療潛力 (MOST 109-2320-B-010 -031 -MY3，主持人，2020/08/01~ 2023/07/31).
2. 阿黴素抑制Cisd2表現及彭祖19號經由活化Cisd2降低阿黴素心毒性之分子機制探討(3/3) (MOST 110-2320-B-A49A-537，主持人，2021/08/01~ 2022/07/31).
3. 防疫科學研究中心計畫，治療組，傳統中藥方劑對於新冠肺炎之臨床觀察及機轉探討(MOST 109-2327-B-010-005，子計畫主持人，2020/06/01~ 2021/12/31).
4. 阿黴素抑制Cisd2表現及彭祖19號經由活化Cisd2降低阿黴素心毒性之分子機制探討(2/3) (MOST 109-2320-B-010 -044，主持人，2020/08/01~ 2021/07/31).
5. 阿黴素抑制Cisd2表現及彭祖19號經由活化Cisd2降低阿黴素心毒性之分子機制探討(1/3) (MOST 108-2320-B-010-010，主持人，2019/08/01~ 2020/07/31).
6. 探討穿心蓮內酯及其衍生物對致癌性p53點突變蛋白之抑制作用及抗癌應用性(106-2320-B-010-006-MY3，主持人，2017/08/01~ 2020/10/31).
7. 抗發炎植物的研究與開發(106-2320-B-077-002-MY3，共同主持人，2017/08/01~ 2020/07/31).
8. 探討hnRNPK蛋白質甲基化修飾促進癌細胞惡性之機制(106-2311-B-010-004-MY3，共同主持人，2017/08/01~ 2020/10/31).
9. 九節茶、台灣及己和薄葉艾納香的活性組成研究(105-2320-B-077-003-，共同主持人，2016/08/01~ 2017/07/31).