–TEACHER PROFILE–

Name：Ching-Mao Chang

Position：Assistant Professor

Phone：

Email: magicbjp@gmail.com; tcmcmc@nycu.edu.tw

Education：

1. D., Graduate Institute of Clinical Medicine, Chang Gung University, Taoyuan, Taiwan
2. D., School of Chinese Medicine, China Medical University, Taichung, Taiwan

Current Employment:

1. Assistant professor, Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
2. Director, Division of Integrative Medicine, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
3. Assistant Professor, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

Employment Record:

1. Visiting Research Scholar, Center for Complementary and Integrative Medicine, Division of Rheumatology, Tufts Medical Center, Boston, US
2. Attending physician (M.D.), Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
3. TCM Chief Resident Physician, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
4. TCM Resident Doctor, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
5. Internship, Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan

Academic Record:

1. Associate Editor, Session of Rheumatology, Frontiers in Medicine, Switzerland
2. Member of Adaptation Committee, Taiwan Herbal Pharmacopeia 4th Edition, Department of Chinese Medicine and Pharmacy, Ministry of Health and Welfare, Taipei, Taiwan

Awards:

1. “Best Teacher Award 2021”, Taipei Veterans General Hospital, 2021
2. “Traditional Chinese Medicine excellent Academic Research Award”: Chinese herbal medicine SS-1 inhibits T cell activation and ameliorates TH responses in Sjögren’s syndrome, Taipei Chinese Medical Association, Taipei, Taiwan, 2021
3. “Traditional Chinese Medicine excellent Academic Research Award”: Stability of a Lupus Nephritis Case after One Year of Integrated Therapy, Taipei Chinese Medical Association, Taipei, Taiwan, 2021
4. “Traditional Chinese Medicine excellent Academic Research Award”: TCM Insomnia OSCE Video education, Taipei, Taiwan, 2021
5. “Distinguished Clinical Teaching Physician Award”, Taipei Veterans General Hospital”, Veterans Affairs Council (VAC), R.O.C, 2020
6. “Traditional Chinese Medicine excellent Academic Research Award”, National Union of Chinese Medical Doctors’Association, R.O.C, 2020
7. “Traditional Chinese Medicine excellent Academic Research Award”: Integrated therapy decreases the mortality of patients with polymyositis and dermatomyositis: A Taiwan-wide population-based retrospective study , Taipei Chinese Medical Association, Taipei, Taiwan, 2020
8. “Traditional Chinese Medicine excellent Academic Research Award”: Laser Acupuncture for Carpal Tunnel Syndrome: A Single-Blinded Controlled Study, Taipei Chinese Medical Association, Taipei, Taiwan, 2020
9. “Excellent Teacher Award”, 108-2 , PBL, Faculty of Medicine, National Yang-Ming University, 2020
10. “Excellent Teacher Award”, 108-1 , PBL, Faculty of Medicine, National Yang-Ming University, 2020
11. “Traditional Chinese Medicine excellent Academic Research Award”, National Union of Chinese Medical Doctors’Association, R.O.C, 2019
12. “Traditional Chinese Medicine excellent Academic Research Award”: Integrated Therapy Improve Urinary Total Protein in Patients with Lupus Nephritis: A Case Report , Taipei Chinese Medical Association, Taipei, Taiwan, 2019
13. “Best Teacher Award 2020”, Taipei Veterans General Hospital, 2020
14. “Excellent Teacher Award”, 107-2 , PBL, Faculty of Medicine, National Yang-Ming University, 2019
15. “Excellent Teacher Award”, 107-2 , PBL, Faculty of Medicine, National Yang-Ming University, 2019
16. “Best Physician Award”, Taipei Veterans General Hospital”, Veterans Affairs Council (VAC), R.O.C, 2018
17. “Traditional Chinese Medicine excellent Academic Research Award”, National Union of Chinese Medical Doctors’Association, R.O.C, 2018
18. “Excellent Teacher Award”, 106-2 , PBL, Faculty of Medicine, National Yang-Ming University, 2018
19. “Best Teacher Award 2018”, Taipei Veterans General Hospital, 2018
20. “Traditional Chinese Medicine excellent Academic Research Award”, National Union of Chinese Medical Doctors’Association, R.O.C, 2017
21. “Best Teacher Award 2017″, Taipei Veterans General Hospital”, 2017
22. “Traditional Chinese Medicine excellent Academic Research Award”: Integrative Therapy Decreases the Risk of Lupus Nephritis in Patients with Systemic Lupus Erythematosus: A Population-Based Retrospective Cohort Study , Taipei Chinese Medical Association, Taipei, Taiwan, 2017
23. “Traditional Chinese Medicine excellent Academic Research Award”: The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren’s syndrome: A Nationwide Population-Based Study , Taipei Chinese Medical Association, Taipei, Taiwan, 2016
24. “Traditional Chinese Medicine excellent Academic Research Award”: How to understand the TCM Zheng, Taipei Chinese Medical Association, Taipei, Taiwan, 2016
25. “Distinguished Clinical Teaching Physician Award”, Taipei Veterans General Hospital”, Veterans Affairs Council (VAC), R.O.C, 2015
26. “Best Intern Award”, China Medical University Hospital, Taichung, Taiwan, 2010
27. “Oral Presentation Excellence Award” in Research Conference, China Medical University, Taichung, Taiwan, 2010

Research Interest:

1. Traditional Chinese Medicine in Allergy, Immunology, Rheumatology：中醫過敏風濕免疫學
2. TCM Clinical trial：中醫藥臨床試驗
3. Sjögren syndrome：修格蘭氏症、乾燥症
4. Systemic Lupus Erythematosus：紅斑性狼瘡
5. Systemic Sclerosis：硬皮症
6. Bioinformatics：生物資訊

Clinical expertise:

1. Sjögren syndrome/Sicca Syndrome (Dry Eye, Dry month)：修格蘭氏症 /乾燥症 (口乾、眼乾)
2. Systemic Lupus Erythematosus：紅斑性狼瘡
3. Systemic Sclerosis：硬皮症
4. Rheumatoid arthritis：類風濕性關節炎
5. Ankylosing spondylitis：僵直性脊椎炎
6. Autoimmune Rheumatic Diseases：自體免疫風濕疾病
7. Dry Eye Syndrome/Keratoconjunctivitis：乾眼症
8. Allergic Rhinitis： 過敏性鼻炎
9. Insomnia/ Sleep disorder：失眠/睡眠障礙
10. Anxiety/Depressive disorder：焦慮、憂鬱症
11. Chronic Fatigue Syndrome： 慢性疲勞症候群
12. Sleep Obstructive Disease/Obstructive Sleep Apnea (OSA)： 睡眠呼吸中止症
13. Gastrointestinal disorder：腸胃道疾病
14. Gastroesophageal reflux disease (GERD)：胃食道逆流
15. Migraine：偏頭痛
16. Irritable Bowel Syndrome：大腸激躁症
17. Dizziness/Vertigo Disorder： 頭昏/眩暈
18. Hepatitis B/C： B/C型肝炎
19. Myofascial pain syndrome：筋肌膜炎症候群
20. Osteoarthritis：退化性關節炎
21. Acupuncture & Moxibustion： 針灸

Research Projects:

1. Using objective measurement signals such as Traditional Chinese Medicine (TCM) constitution, tongue diagnosis, pulse diagnosis, heart rate variation to apply the association research on autoimmune rheumatic diseases (Sjögren syndrome) and Dry eye syndrome
2. Application of deep learning Research on TCM Tongue Diagnosis and TCM Pulse Diagnosis and TCM Prescription Analysis.
3. Gene, proteomics and oral microbiome of autoimmune rheumatic diseases.
4. Clinical efficacy of Chinese herbal medicine and acupuncture in autoimmune rheumatic diseases.
5. Real-world big data research on autoimmune rheumatic diseases.
6. Research on the role of mitochondria in anti-inflammation, anti-oxidation and immune-modulation of autoimmune rheumatic diseases.

Courses：

1. Clinical Literature Review of Traditional Chinese Medicine and Acupuncture
2. Special Topic on Traditional Chinese Medicine for Autoimmune Disease

-ACADEMIC WORKS–

A: Referred Paper

1. Tieh-Cheng Fu, Yen-Ying Kung, Jr-Rung Lin, Ching-Mao Chang*. Editorial: Objective Diagnosis and Management of Immune-mediated Rheumatic Diseases. Frontiers in Medicine. 2023 (SCI, 2022 IF= 5.058)
2. Hsin-Yuan Chen, Jin-Huang Wu, Hong-Chun Lin, Yu-Ting Su, Chien-Ming Yen, Ching-Mao Chang*. Commentary: Efficacy and Safety of Acupuncture on Symptomatic Improvement in Primary Sjögren’s Syndrome – A Randomized Controlled Trial. Frontiers in Medicine. 2023 (SCI, 2022 IF= 5.058)
3. Tsung-Hsing Lin#, Cheng-Chia Yang#, Shih-Yu Lee, Ching-Mao Chang, I-Ju Tsai, Cheng-Yu Wei*, Chun-Pai Yang*. The effect of bright light therapy on migraine with sleep disturbance: protocol for a prospective, observational cohort study. Frontiers in Aging Neuroscience. 2023 (SCI, 2022 IF= 5.702)
4. 孔德馨，蘇郁婷，林虹均，吳璟凰，張清貿*. 修格蘭氏症候群之中醫舌脈持續評估病例報告. 中醫藥雜誌. 2023
5. 吳育瑜，顏見明，林虹均，陳國豐，張清貿*. 中藥治療僵直性脊椎炎之病例報告. 中醫藥研究論叢. 2023
6. 洪慈瑩，陳國豐，林虹均，顏見明，張清貿*. 滋陰降火及清熱利溼治療菊地氏病. 中醫藥研究論叢. 2023
7. Ching-Mao Chang, Jr-Rung Lin, Tieh-Cheng Fu*. Associations between sarcopenia, heart failure and myocardial infarction in patients with systemic lupus erythematosus and rheumatoid arthritis. Frontiers in Medicine. 2022 (SCI, 2022 IF= 5.058)
8. Hong-Chun Lin, Chien-Ming Yen, Kuo-Feng Chen, Yen-Ying Kung, Yung-Hung Hsieh, Ching-Mao Chang*. The banned herbal medicine induced liver injury in Taiwan. Hepatology International. 2022 (SCI, 2022 IF= 9.029)
9. Chun-Pai Yang, Ching-Mao Chang, Cheng-Chia Yang, Carmine M. Pariante, Kuan-Pin Su*. Long COVID and Long Chain Fatty Acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19. Brain, Behavior, and Immunity. 2022 (SCI, 2022 IF=19.227)
10. Ching-Mao Chang, Po-Chang Wu, Jr-Rung Lin, Yeong-Jian Jan Wu, Shu-Fen Lo, Yin-Tzu Hsue, Joung-Liang Lan, Tai-Long Pan, Yu-Ting Wu, Kuang-Hui Yu*, Yau-Huei Wei*, Hen-Hong Chang*. Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome. Frontiers in Pharmacology. 2021 (SCI, 2022 IF= 5.988)
11. Ching-Mao Chang#, Chun-Pai Yang#, Cheng-Chia Yang, Po-Hsuan Shih, Shuu-Jiun Wang*. Evidence of Potential Mechanisms of Acupuncture from Functional MRI Data for Migraine Prophylaxis. Current Pain and Headache Reports. 2021 (SCI, 2022 IF= 3.904)
12. Gilbert Aaron Lee#, Ching-Mao Chang#, Ying Chieh Wu, Ruo-yu Ma, Cheng-Yu Chen, Yin-Tzu Hsue, Nan-Shih Liao*, Hen-Hong Chang*. Chinese herbal medicine SS-1 inhibits T cell activation and ameliorates TH responses in Sjögren’s syndrome. Journal of the Formosan Medical Association. 2021 (SCI, 2022 IF= 3.904)
13. Ho-Lin Lu#, Ching-Mao Chang#, Po-Chun Hsieh, Jia-Chi Wang, Yen-Ying Kung*. The effects of acupuncture and related techniques on patients with rheumatoid arthritis: A systematic review and meta-analysis. Journal of the Chinese Medical Association. 2021 (SCI, 2022 IF= 3.396)
14. Chun-Pai Yang, Chih-Sung Liang, Ching-Mao Chang, Cheng-Chia Yang, Po-Hsuan Shih, Yun-Chain Yau, Kuo-Tung Tang*, Shuu-Jiun Wang*. Comparison of New Pharmacologic Agents With Triptans for Treatment of Migraine-A Systematic Review and Meta-analysis. JAMA Network Open. 2021 (SCI, 2022 IF= 13.366)
15. Chun-Pai Yang#, Bing-Yan Zeng#, Ching-Mao Chang, Po-Hsuan Shih, Cheng-Chia Yang, Ping-Tao Tseng*, Shuu-Jiun Wang*. Comparative effectiveness and tolerability of the pharmacology of monoclonal antibody reacting to calcitonin gene-related peptide for the prevention of chronic migraine: A network meta-analysis of randomized controlled trials. Neurotherapeutics. 2021 (SCI, 2021 IF= 7.620)
16. Yun-Chain Yau#, Chun-Pai Yang#, Ching-Po Lin, I-Ju Tsai, Ching-Mao Chang, Cheng-Chia Yang, Po-Hsuan Shih, Yin-Yin Liao*. The morphological and dynamic changes of ultrasound in the evaluation of effects of oral steroids treatment for patients with carpal tunnel syndrome. Diagnostics. 2021 (SCI, 2021 IF=3.706)
17. Chun-Pai Yang#, Kuo-Ting Huang#, Ching-Mao Chang, Cheng-Chia Yang, Shuu-liun Wang*. Acute Treatment of Migraine: What has changed in pharmacotherapies? Neurology India. 2021 (SCI, 2021 IF= 2.117)
18. Diem Ngoc Hong Tran, I-Hsuan Hwang, Fun-Jou Chen, Yuan-Pu Tseng, Ching-Mao Chang, Shih-Jen Tsai, Jen-Lin Yang, Ta-Peng Wu, Chung-Hua Hsu, Fang-Pey Chen, Yen-Ying Kung*, Core Prescription Pattern of Chinese Herbal Medicine for Depressive Disorders in Taiwan: A Nationwide Population-Based Study, Integrative Medicine Research. 2021 (SCI, 2021 IF= 2.368)
19. 吳璟凰，林虹均，陳國豐，張清貿*. 針刺治療肌少症之文獻回顧與展望. TBMJ 勤樸夏勤訊. 2021
20. 馬碩煒，林虹均，曾偉婷，張清貿*. 中藥治療系統性紅斑性狼瘡合併狼瘡腎炎病例報告. 中醫藥雜誌. 2021
21. Wei-Ting Tseng, Po-Hsuan Shih, Hong-Chun Lin, Pei-Wen Wu, Yen-Ying Kung, Ching-Mao Chang*. Stability of a Lupus Nephritis Case after One Year of Integrated Therapy. EC Gastroenterology and Digestive System. 2020
22. 吳珮雯，施柏瑄，林虹均，曾偉婷，張清貿*. 臺灣本土治療消化性潰瘍疾病之整合醫學研究回顧. 中醫藥新知. 2020
23. 黃偉勝，林虹均，曾偉婷，張清貿*. 中藥治療修格蘭氏症候群合併系統性紅斑狼瘡病例報告. 中醫藥雜誌. 2020
24. 陳國豐，曾偉婷，林虹均，張清貿*. 中藥緩解修格蘭氏症合併橋本氏甲狀腺炎之病例報告. 中醫藥研究論叢. 2020
25. Ching-Mao Chang^#, Po-Hsuan Shih^#, Tzeng-Ji Chen, Wen-Chao Ho*, Chun-Pai Yang*. Integrated Therapy Decreases the Mortality of Patients with Polymyositis and Dermatomyositis: A Taiwan-wide Population-Based Retrospective Study. Journal of Ethnopharmacology. 2019, 236: 70-81 (SCI, 2021 IF= 5.195)
26. Chi-Wen Juan#, Ming-Hong Chang, Tsung-Hsing Lin#, Kai-Lin Hwang, Tieh-Cheng Fu, Po-Hsuan Shih, Ching-Mao Chang*, Chun-Pai Yang*. Laser acupuncture for carpal tunnel syndrome: A single-blinded controlled study. Journal of Alternative and Complementary Medicine. 2019 (SCI, 2020 IF= 2.256)
27. Ching-Hsiung Liu, Yen-Ying Kung, Chun-Liang Lin, Jen-Lin Yang, Ta-Peng Wu, Hong-Chun Lin, Yang-Kai Chang, Ching-Mao Chang, Fang-Pey Chen*. Therapeutic Efficacy and the Impact of the Effect of Acupuncture to Treat Sciatica: A Randomized Controlled Pilot Study. Journal of Pain Research. 2019 (SCI, 2019 IF= 2.236)
28. Ching-Hsiung Liu, Yen-Ying Kung, Tzu-Chen Yeh, Pei-Shan Hsu, Ching-Ju Yang, Chou-Ming Cheng, Hong-Chun Lin, Jen-Lin Yang, Ta-Peng Wu, Ching-Mao Chang, Jen-Chuen Hsieh, Fang-Pey Chen*. Differing Spontaneous Brain Activity in Healthy Adults with Two Different Body Constitutions: A Resting-State Functional Magnetic Resonance Imaging Study. Journal of Clinical Medicine. 2019, 8(7), 951 (SCI, 2018 IF= 5.688)
29. Pei-Wen Wu^#, Po-Hsuan Shih^#, Yen-Ying Kung, Fang-Pey Chen, Ching-Mao Chang*. Integrated Therapy Improve Urinary Total Protein in Patients with Lupus Nephritis: A Case Report. Complementary Therapies in Medicine. 2018 (SCI, 2016 IF= 2.013)
30. Tieh-Cheng Fu, Chaur-Chin Chen, Ching-Mao Chang*, Hen-Hong Chang, Hsueh-Ting Chu*. Analysis of Exercise-induced Periodic Breathing Using an Autoregressive Model and the Hilbert-Huang Transform. Computational and Mathematical Methods in Medicine. 2018 (SCI, 2019 IF= 1.563)
31. Ta-Peng Wu, Cheng-Hung Tsai, Yu-Ting Su, Chu-Chiao Wang, Tzeng-Ji Chen, Ching-Mao Chang, Fang-Pey Chen*. The Evaluation of Professional Divisions of TCM in Taiwan through Patient Visit Records of 2012. International Journal of Environmental Research and Public Health. 2018 (SCI, 2016 IF= 2.145)
32. Ching-Mao Chang*. Integrated Therapy for Chronic Hepatitis in Taiwan. EC Gastroenterology and Digestive System. 2018
33. 張凱惟, 張清貿, 陳方佩, 龔彥穎*. 中醫治療主動脈瓣狹窄病例之理論與病例報告. 中醫藥研究論叢. 2018, 21(1): 171-190 (in Chinese)
34. 張凱惟, 施柏瑄, 謝承運, 曾元卜, 陳方佩, 龔彥穎, 張清貿*. 各國中草藥質量標準比較：以藥材三七為例. 台北市中醫醫學雜誌. 2017 (in Chinese)
35. Yi-Ting Kuo, Hou-Hsun Liao, Jen-Huai Chiang, Bor-Chyuan Chen, Ching-Mao Chang, Ming-Hsien Yeh, Tung-Ti Chang, Mao-Feng Sun, Chia-Chou Yeh, Hung-Rong Yen*. Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients with Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study. Integrative Cancer Therapies. 2017 (SCI, 2016 IF= 1.923)
36. Ching-Mao Chang, Po-Chang Wu, Jen-Huai Chiang, Yau-Huei Wei, Fang-Pey Chen, Tzeng-Ji Chen, Tai-Long Pan, Hung-Rong Yen*, Hen-Hong Chang*. Integrative therapy decreases the risk of lupus nephritis in patients with systemic lupus erythematosus: A population-based retrospective cohort study. Journal of Ethnopharmacology. 2017,196: 201-212 (SCI, 2015 IF= 3.055)
37. Fang-Pey Chen, Ching-Mao Chang, Ta-Peng Wu, Jen-Lin Yang, Yen-Ying Kung, Yi-Hsiang Huang, Chien-Wei Su, Keng-Hsin Lan, Shu-Chiung Chiang, Shinn-Jang Hwang*. Clinical efficacy of Rong-Yang-Jyh-Gan-Tang on patients with chronic hepatitis C: A double-blinded randomized placebo-controlled crossover study. Journal of Ethnopharmacology. 2017,196: 1-8 (SCI, 2015 IF= 3.055)
38. 張清貿^#, 施柏瑄^#, 楊仕哲*. 心腦主神明學說的沿革. 中醫藥雜誌. 2017, 28(1): 2801001 (in Chinese)
39. 張凱惟, 張清貿, 陳方佩, 楊仁鄰*. 攝護腺癌合併骨轉移疼痛之針刺治療病例報告. 臺灣中醫醫學雜誌. 2017, 15(2): 5-16 (in Chinese)
40. 張雅婷, 張清貿, 龔彥穎, 陳方佩, 吳大鵬*. 針刺治療癌症疼痛–病例報告. 臺灣中醫醫學雜誌. 2017, 15(2): 17-30 (in Chinese)
41. Shu-Wen Weng, Bor-Chyuan Chen, Yu-Chiao Wang, Chun-Kai Liu, Mao-Feng Sun, Ching-Mao Chang, Jaung-Geng Lin*, Hung-Rong Yen*. Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study. Evidence-Based Complementary and Alternative Medicine. 2016: 3164105 (SCI, 2015 IF=1.931)
42. Tieh-Cheng Fu, Yi-Chung Lin, Ching-Mao Chang, Wei-Ling Chou, Pei-Hsun Yuan, Min-Hui Liu, Chao-Hung Wang, Juei-Chao Chen, Hen-Hong Chang*, Tai-Long Pan. Validation of a new simple scale to measure symptoms in heart failure from traditional Chinese medicine view: a cross-sectional questionnaire study. BMC Complementary and Alternative Medicine, 2016, 16: 342 (SCI, 2015 IF=1.987)
43. 施柏瑄#, 洪國棟#, 林奕中, 張清貿*. 僵直性脊椎炎之中醫藥文獻回顧. 中醫藥研究論叢. 2016, 19(2): 99-112 (in Chinese)
44. Hen-Hong Chang, Shue-Fen Luo, Yin-Tzu Hsue, Ching-Mao Chang, Tzung-Yan Lee, Ming-Ling Hsu, Yu-Chuen Huang, Yu-Jen Chen*. Modulation of Endothelial Injury Biomarkers by Traditional Chinese Medicine LC in Systemic Lupus Erythematosus Patients Receiving Standard Treatments. Scientific Reports. 2016, 6: 19622 (SCI, 2014 IF=5.578)
45. 謝承運, 張清貿, 陳方佩, 吳大鵬, 楊仁鄰, 龔彥穎*. 雷諾氏症候群的中醫診治病例報告. 北市中醫會刊. 2016, 22(1): 55-64 (in Chinese)
46. Tom Fleischer, Tung-Ti Chang, Jen-Huai Chiang, Ching-Mao Chang, Ching-Yun Hsieh, Hung-Rong Yen*. Adjunctive Chinese Herbal Medicine Therapy Improves Survival of Patients with Chronic Myeloid Leukemia: A Nationwide Population-based Cohort Study. Cancer Medicine. 2015, 5: 640-648 (SCI, 2014 IF=2.5)
47. 蔡承宏, 張清貿, 龔彥穎, 陳方佩, 吳大鵬*. 針刺治療嬰兒臂神經叢麻痺. 臺灣中醫醫學雜誌. 2015, 13(2): 13-24 (in Chinese)
48. 蔡承宏, 張清貿, 龔彥穎, 陳方佩, 吳大鵬*. 針刺緩解粒線體疾病病童疑似肌陣攣發作之病例報告. 中醫藥研究論叢. 2015, 18(2): 117-127 (in Chinese)
49. Ching-Ying Huang, Wan-Yu Lai, Mao-Feng Sun, Che-Chen Lin, Bor-Chyuan Chen, Ching-Mao Chang, Hong-Jen Lin, Chung-Hsien Yang, Kuo-Chin Huang, Hung-Rong Yen*. Prescription Patterns of Traditional Chinese Medicine for Peptic Ulcer Disease in Taiwan: A Nationwide Population-based Study. Journal of Ethnopharmacology. 2015, 176: 311-320 (SCI, 2014 IF= 2.998)
50. Ming-Cheng Huang, Fu-Tzu Pai, Che-Chen Lin, Ching-Mao Chang, Hen-Hong Chang, Yu-Chen Lee, Mao-Feng Sun, Hung-Rong Yen*: Characteristics of Traditional Chinese Medicine Use in Patients with Rheumatoid Arthritis in Taiwan: A Nationwide Population-Based Study. Journal of Ethnopharmacology. 2015, 176: 9-16 (SCI, 2014 IF=2.988)
51. Fang-Pey Chen, Ching-Mao Chang, Jing-Huei Shiu, Jen-Hwey Chiu, Ta-Peng Wu, Jen-Lin Yang, Yen-Ying Kung, Fun-Jou Chen, Chang-Ming Chern*, Shinn-Jang Hwang*: A Clinical Study of Integrating Acupuncture and Western Medicine in Treating Patients with Parkinson’s Disease. The American Journal of Chinese Medicine. 2015, 43(3): 407-423 (SCI, 2014 IF= 2.625)
52. Ching-Mao Chang, Hsueh-Ting Chu, Yau-Huei Wei, Fang-Pey Chen, Shengwen Wang, Po-Chang Wu, Hung-Rong Yen, Tzeng-Ji Chen*, Hen-Hong Chang*: The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren’s syndrome: A Nationwide Population-Based Study. Scientific Reports. 2015, 5: 9541 (SCI, 2014 IF=5.578)
53. 張清貿, 施柏瑄, 朱學亭, 陳方佩*. 該如何理解「證」？– 中醫證型現代研究的定性與定量, 臨床醫學. 2014 (73): 189-195 (in Chinese)
54. Fang-Pey Chen, Ching-Mao Chang, Shinn-Jang Hwang*, Yu-Chun Chen, Fun-Jou Chen: Chinese herbal prescriptions for osteoarthritis in Taiwan: analysis of national health insurance dataset. BMC Complementary and Alternative Medicine. 2014, 14: 91 (SCI, 2013 IF=1.877)
55. Ching-Mao Chang, Wen-Hsiang Wu, Benjamin Ing-Tiau Kuo, Tzung-Yan Lee, Chia-Yu Liu, Hen-Hong Chang*: Using A Questionnaire among Patient, Resident Doctor and Senior Supervisor: Are their Answers the Same? Complementary Therapies in Medicine. 2014, 22: 296-303 (SCI, 2013 IF=2.216)
56. Hsueh-Ting Chu, Han Lin, Theresa Tsun-Hui Tsao, Chun-Fan Chang, William WL Hsiao, Tze-Jung Yeh, Ching-Mao Chang, Yen-Wenn Liu, Tse-Yi Wang, Ko-Chun Yang, Tsung-Jui Chen, Jen-Chih Chen, Kuang-Chi Chen, Cheng-Yan Kao*: Genotyping of human neutrophil antigens (HNA) from whole genome sequencing data. BMC Medical Genomics. 2013, 6: 31 (SCI, 2013 IF=3.91)
57. Hsueh-Ting Chu, William W.L. Hsiao, Theresa TH Tsao, Ching-Mao Chang, Yen-Wenn Liu, Chen-Chieh Fan, Han Lin, Hen-Hong Chang, Tze-Jung Yeh, Jen-Chih Chen, Dun-Ming Huang, Chaur-Chin Chen, Cheng-Yan Kao*: Quantitative assessment of mitochondrial DNA copies from whole genome sequencing. BMC Genomics: 2012, 13(Suppl 7): S5 (SCI, 2013 IF=4.04)
58. Ching-Mao Chang, Tin-Yun Ho, Hsueh-Ting Chu, Chia-Cheng Li, Yung-Hsien Chang* A mathematical method to differentiate the effects of “Aconitum carmichaeli Debx” in different prescriptions. Mid-Taiwan Journal of Medicine: 2008, 13(3): 152-15. (in Chinese)

B: Conference Paper

1. 孔德馨、蘇郁婷、林虹均、陳國豐、張清貿*. 利用中醫舌脈診對修格蘭氏症候群進行持續性評估. 2022年第14屆台北國際中醫藥學術論壇: 2022
2. 吳育瑜、顏見明、林虹均、陳國豐、張清貿*. 清熱除溼、活血通絡、滋養肝腎治療僵直性脊椎炎. 2022年第14屆台北國際中醫藥學術論壇: 2022
3. 洪慈瑩、陳國豐、林虹均、顏見明、張清貿*. 滋陰降火及清熱利溼治療菊地氏病. 2022年第14屆台北國際中醫藥學術論壇: 2022
4. 吳璟凰，曾偉婷，林虹均，陳國豐，張清貿*. 清熱化溼、疏肝健脾、行氣活血治療克隆氏症. 2021年第13屆台北國際中醫藥學術論壇: 2021
5. 黃偉勝, 林虹均, 曾偉婷, 張清貿*: 滋陰潤燥、活血通絡治療修格蘭氏症候群合併身性紅斑狼瘡之病例報告. 2020年第12屆台北國際中醫藥學術論壇: 2020
6. 陳國豐, 曾偉婷, 林虹均, 施柏瑄, 張清貿*: 橋本甲狀腺炎之中醫藥文獻回顧. 2020年第12屆台北國際中醫藥學術論壇: 2020
7. 馬碩煒, 曾偉婷, 林虹均, 張清貿*: 祛風除濕、清熱育陰、活血化瘀治療系統性紅斑性狼瘡合併狼瘡腎炎. 2020年第12屆台北國際中醫藥學術論壇: 2020
8. 林虹均, 施柏瑄, 朱學亭, 曹榮穎, 陳方佩, 張清貿*: 利用數學模式分析方法探討歷代艾附暖宮丸同名方劑之異同性. 2018年第10屆台北國際中醫藥學術論壇: 2018
9. 張卜云, 施柏瑄, 龔彥穎, 謝承運, 曾元卜, 陳方佩, 張清貿*: 中醫藥治療血管炎之文獻回顧. 2018年第10屆台北國際中醫藥學術論壇: 2018
10. 曾偉婷, 張清貿, 陳方佩, 吳大鵬, 楊仁鄰, 龔彥穎*: 影響生長相關激素之中藥探討. 2018年第10屆台北國際中醫藥學術論壇: 2018
11. 孫彩霞, 張清貿, 陳方佩, 吳大鵬, 楊仁鄰, 龔彥穎*: 中醫輔助治療類肉瘤症病例報告. 2018年第10屆台北國際中醫藥學術論壇: 2018
12. 廖雅嫻, 張清貿, 陳方佩, 吳大鵬, 楊仁鄰, 龔彥穎*. 木防己湯緩解類風濕性關節炎患者之主動脈辦狹窄. 2018年第10屆台北國際中醫藥學術論壇: 2018
13. 蘇郁婷, 蔡承宏, 陳方佩, 陳曾基, 張清貿, 王楚嶠, 吳大鵬*: 臺灣中醫專科醫師制度之趨勢探討. 2018年第10屆台北國際中醫藥學術論壇: 2018
14. 張凱惟, 陳方佩, 吳大鵬, 楊仁鄰, 龔彥穎, 張清貿*: 各國藥典對三七品質管制比較. 2017年第9屆台北國際中醫藥學術論壇: 2017
15. 張雅婷, 張清貿, 陳方佩, 吳大鵬, 楊仁鄰, 龔彥穎*: 抗凝血劑與中藥併用產生不良反應風險之文獻回顧. 2017年第9屆台北國際中醫藥學術論壇: 2017
16. 張毓庭, 張清貿, 陳方佩, 龔彥穎, 楊仁鄰, 吳大鵬*: 針刺治療腦膜瘤術後神經學症狀病例報告. 2017年第9屆台北國際中醫藥學術論壇: 2017
17. 吳珮雯, 張清貿, 陳方佩, 楊仁鄰, 龔彥穎*: 突發性感覺神經性耳聾之中醫針灸治療現況文獻回顧., 2017年第9屆台北國際中醫藥學術論壇: 2017
18. 林奇玄, 張清貿, 陳方佩, 吳大鵬, 楊仁鄰, 龔彥穎*: 臺灣孕婦禁忌中藥之安全性探討–文獻回顧與分析. 2017年第9屆台北國際中醫藥學術論壇: 2017
19. 張嘉芸, 張清貿, 陳方佩, 龔彥穎, 楊仁鄰, 吳大鵬*: 中西醫結合治療頭頸癌放射線治療後下頷骨壞死病例報告. 2017年第9屆台北國際中醫藥學術論壇: 2017
20. Ching-Mao Chang, Po-Hsuan Shih, Shengwen Wang, Hen-Hong Chang, Fang-Pey Chen, Hsueh-Ting Chu*: A Wiki-Based Traditional Chinese Medicine Formulary Knowledge System for Comparative Herb-Drug Interaction and Formula Zheng Analysis. 17th International Congress of Oriental Medicine (ICOM): 2014
21. Ching-Mao Chang, Hsueh-Ting Chu, Yau-Huei Wei, Fang-Pey Chen, Shengwen Wang, Po-Chang Wu, Hung-Rong Yen, Tzeng-Ji Chen*, Hen-Hong Chang*: The Core Pattern of Chinese Herbal Medicines for Sjögren’s Syndrome in Taiwan from National Health Insurance Research Database between year 2002 to 2011. 13th Meeting of Consortium for Globalization of Chinese Medicine (CGCM): 2014
22. Ching-Mao Chang, Yi-Chung Ling, Po-Chang Wu, Hen-Hong Chang*: The Change of Symptoms in the Treatment of Traditional Chinese Medicine for Systemic Lupus Erythematosus. 13th Meeting of Consortium for Globalization of Chinese Medicine (CGCM): 2014
23. Tieh-Cheng Fu, Yi-Chung Ling, Wei-Ling Chou, Ching-Mao Chang, Jong-Shyan Wang*, Hen-Hong Chang*: The Application of TCM Inquiry Diagnosis in the Functional Classification of Heart Failure. 13th Meeting of Consortium for Globalization of Chinese Medicine (CGCM): 2014
24. Yu-Yun Huang, Fang-Pey Chen*, Shinn-Jang Hwang, Maw-Shiou Jong, Fun-Jou Chen, Yi-Tsau Huang, Ching-Mao Chang: Potential Herb-Drug Interaction between Ginseng and Western Medicine in Taiwan: Analysis of National Health Insurance Dataset. International Conference of Traditional and Complementary Medicine on Health (ICTCMH): 2013
25. Ching-Mao Chang, Tin-Yun Ho, Po-Hsuan Shih, Hsueh-Ting Chu*: An Online Platform for Multiple Factors Analysis of Traditional Chinese Medicine. 2012 Cloud Computing Workshop (2012 CCW): 2012
26. Dun-Ming Huang, Hsueh-Ting Chu, Ching-Mao Chang and Cheng-Yan Kao*: Epitope Prediction for Multi-epitope HCA661 Liver Cancer Vaccines. World Congress on Engineering and Computer Science: 2012
27. Ching-Mao Chang, Benjamin Ing-Tiau Kuo, Wen-Hsiang Wu, Chia-Yu Liu, Hen-Hong Chang*: The Consistency Among Patients, Resident Doctor and Senior Supervisor in using a Traditional Chinese Medicine Questionnaire. 10th Meeting of Consortium for Globalization of Chinese Medicine (CGCM): 2011
28. Ching-Mao Chang, Horng-Sheng Shiue, Yun-Shien Lee, Li-Tzu Chin, Hen-Hong Chang*: The effect of herbal paste treatment on patients with Allergic Rhinitis. 10th Meeting of Consortium for Globalization of Chinese Medicine (CGCM): 2011
29. Ching-Mao Chang, Hsueh-Ting Chu, Chia-Cheng Lee, Hsin-Yi Lo, Jaw-Chyun Chen, Chien-Yun Hsiang, Chang,Yung-Hsien, Tin-Yun Ho*: HerbBlast – A program for similarity and ontology analysis of Chinese herbal medicine. Bioinformatics in Taiwan: 2006

C：專書

1. Pin-Chung Huang, Fu-Chi Yang, Ching-Mao Chang, Chun-Pai Yang*. Chapter 4: Targeting the 5-HT1B/1D and 5-HT1F receptors for acute migraine treatment. Update on Emerging Treatments for Migraine, Elsevier: Progress in Brain Research (ISBN: 978-0-12-821108-3), 2020(255):P.99-P.121

-RESEARCH PROJECT–

1. 國家科學及技術委員會

   1. 利用口腔微生物菌相探討針刺風池穴合併攢竹穴治療乾眼症與修格蘭氏症口眼乾燥症狀之立即性與長期性治療效果 (NSTC-111-2320-B-075-006-MY2)，主持人，08~2024.07，國科會計畫，ClinicalTrials.gov：NCT04877483
   2. 服務學習模式應用於醫學人文教育成效評估–以海外地區傳統醫療服務暨專業人才培訓為例 (MOST-109-2511-H-075-002)，主持人，08~2022.07，國科會計畫

   
   臺北榮民總醫院院內計畫

   1. 評估中藥茶包VGH-DESJS-1在乾眼症與修格蘭氏症口眼乾燥症狀之使用 (V112C-190)，主持人，01~2023.12，臺北榮民總醫院院內計畫，ClinicalTrials.gov：NCT05656196
   2. 利用DNA Exome sequencing技術探索修格蘭氏症之基因序列與中醫體質、舌診、脈診之相關性研究 (第二年：整合功能性蛋白質體學及口腔微生物菌相) (V109B-034)，主持人，01~2020.12，臺北榮民總醫院院內計畫，ClinicalTrials.gov：NCT03935373
   3. 利用DNA Exome sequencing技術探索修格蘭氏症(Sjögren’s syndrome)之基因序列與中醫體質、舌診、脈診之相關性研究 (V108B-031)，主持人，01~2019.12，臺北榮民總醫院院內計畫，ClinicalTrials.gov：NCT03935373
   4. 利用IFN-γ誘導人類下顎唾液腺細胞模型探討修格蘭氏症中醫健保資料庫前十大中藥單方之粒線體抗氧化機轉 (V106A-006)，主持人，01~2017.12，臺北榮民總醫院院內計畫
   5. 生物資訊在傷寒方的應用 – 傷寒方組方邏輯之探討(NSC97-2815-C-039-061-B)，大專生專題計畫專題生，07~2009.02，國科會大專生專題計畫

-Laboratory Introduction-

AIDDES Lab

自體免疫暨乾眼症客觀量測實驗室

Autoimmune Disease and Dry Eye Syndrome Objective Measurements Lab

Research Directions:

1. The application of objective measurements such as traditional Chinese medicine constitution, tongue diagnosis, pulse diagnosis, heart rate variability in the correlational study of autoimmune rheumatic diseases (Sjögren’s syndrome) and dry eye syndrome.
2. Research on the application of artificial intelligence and deep learning in traditional Chinese medicine tongue and pulse diagnosis in and Chinese herbal prescription.
3. Genomic sequencing, proteomics, and oral microbiome of autoimmune rheumatic diseases.
4. Efficacy analysis of traditional Chinese medicine and acupuncture in autoimmune rheumatic diseases.
5. Real-world big data research in autoimmune rheumatic diseases.
6. Research on anti-inflammatory, antioxidant, and mitochondrial metabolic function in autoimmune rheumatic diseases.

Courses:

1. Clinical Literature Review of Traditional Chinese Medicine and Acupuncture
2. Special Topic on Traditional Chinese Medicine for Autoimmune Disease

BIOGRAPHY
Dr. Chang is a Director/Attending Physician (M.D.) in the Division of Integrative Medicine, Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, and an Assistant Professor in the Faculty of Medicine, National Yang Ming Chiao Tung University (Taipei). Dr. Chang was awarded his Ph.D. from the Graduate Institute of Clinical Medical Sciences (GICM), Chang Gung University, Taoyuan, Taiwan. His Ph.D. study, The Efficacy of Chinese Herbal Formula on Sjögren’s syndrome and its Mechanism of Anti-oxidative and Immune Modulatory Effects, reflects his ongoing fascination with the ability of TCM treatment to not only relieve but also modify the debilitating symptoms associated with Sjögren’s syndrome, including gastrointestinal discomfort, poor appetite, xerostomia and aphthous ulcer. Since graduating with his Ph.D., Dr. Chang has received many tributes in recognition of his excellent guidance offered to younger clinicians and researchers, including “Best Teacher Award”, “Traditional Chinese Medicine Excellent Academic Research Award”, and “Distinguished Clinical Teaching Physician Award” from several institutions: Taipei Veterans General Hospital, the Taipei Chinese Medical Association, National Yang Ming Chiao Tung University, and the National Union of Chinese Medical Doctors’ Association.

RESEARCH INTERESTS
Dr. Chang specializes in traditional Chinese medicine and rheumatology. His main research interests involve TCM clinical trials, Sjögren’s syndrome, systemic lupus erythematosus, systemic sclerosis, and bioinformatics studies. As a key developer of the novel Chinese herbal medicine SS-1 (a triple combination of Chinese herbal preparations consisting of extracts of Gan-Lu-Yin, Sang-Ju-Yin, and Xuefu-Zhuyu-Decoction), he has applied SS-1 in the clinic with very successful outcomes in patients with Sjögren’s syndrome. He is particularly keen on being involved in research collaborations that include biotechnology, bioinformatics and biopharmaceutics.

Clinical expertise:
Sjögren’s syndrome/sicca syndrome (dry eye, dry mouth): 修格蘭氏症 /乾燥症 (口乾、眼乾)
Systemic Lupus Erythematosus: 紅斑性狼瘡
Systemic sclerosis: 硬皮症
Rheumatoid arthritis: 類風濕性關節炎
Autoimmune rheumatic diseases: 自體免疫風濕疾病